Urokinase is indicated for lysis of blood clots in the following conditions:

 - Extensive acute proximal deep vein thrombosis
 - Acute massive pulmonary embolism
 - Acute occlusive peripheral arterial disease with limb threatening ischaemia
 - Thrombosed arteriovenous haemodialysis shunts
 - Thrombosed intravascular catheters and cannulae

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